List of Pharma Companies in US have a significant impact on global health, prosperity, and economic productivity. 

Most of the top US pharmaceutical companies are multinational companies that are engaged in research and development, manufacturing, marketing, and distribution of chemical and biological drugs for humans as well as veterinary use.

Pharma manufacturing companies in the USA have grown at fast pace compared to other countries.

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As per the statista, pharmaceutical companies have accounted for nearly half of the global sales revenue in recent years.

As per Statista, five out of 10 leading pharma companies worldwide are from the US.

Thus, despite significant economic challenges, big pharmaceutical companies in USA did an outstanding job in the research and development of new medicines that save a life, increasing life span, reducing suffering, and prevent surgeries.

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Let’s see the list of pharmaceutical companies in the US that are ruling in the world.

Top List of Pharma Companies in US by Revenue

List of Pharma Companies in US

1. Johnson and Johnson

Revenue 2021: $93.77 billion

Headquarters: New Brunswick, New Jersey

Jhonson, and Jhonson was founded by Robert wood Jhonson in the year 1886. Pharmaceuticals, medical devices, and consumer-packaged goods are its USP. 

This one of the top list of US pharmaceutical companies is headquartered in New Brunswick, New Jersey, and operates more than 250 subsidiaries in 60+ countries with 144,500 employees in 2021.

Since the year 2012, J&J has been able to maintain the top position despite strong competition from Pfizer. 

In the year 2021, the company generated a revenue of about $93.77 billion majority of which is contributed by pharma products. 

This shows about a 13% increase in revenue compared to 2020, as the darzalex made sales of $6 billion, Stelara made sales of more than $18 billion, and the covid vaccine made sales of $2.4 billion.

Prostate cancer medicine Erleada and the schizophrenia franchise are other growth contributors within the pharma group.

2) Pfizer

Revenue 2021: $81.29 billion

Headquarters: New York City.

Founded in the year 1868 by two cousins Charles Pfizer and Charles Erhart, Pfizer is headquartered in New York City.

Pfizer is one of the largest pharmaceutical manufacturing companies in the US and operates through two divisions namely Pfizer innovative health and Pfizer essential health. 

Its products comprise vaccines and medications for a wide range of applications including immunology, cardiology, endocrinology, and neurology.

The total revenue generated in the year 2021 was $81.29 billion, out of which $37 billion is contributed by the covid vaccine.

Eliminating the revenue generated by the covid vaccine, there is a growth of 44% in revenue generation compared to the year 2020.

3) AbbVie.Inc

Revenue 2021: $56.197billion

Headquarters: Lake Bluff, Illinois.

Founded in the year 2013, AbbVie is an American publicly traded pharma manufacturing companies in USA headquartered at Lake Bluff, Illinois, USA as a spin-off of Abbott Laboratories.

It was founded by Dr. Wallace C. Abbott.

This company is actively involved in developing, producing, and marketing biopharmaceuticals and small-molecule drugs.

The revenue generated in the year 2021 was $56.197 billion with an increase of 22.69% from the year 2020.

In this increased revenue generation, the highest contributing products were Humira and Imbruvika. Humira made sales of almost $20.1 billion.

4) Merck & Co

Revenue 2021: $48.77 billion

Headquarters: Kenilworth, New Jersey

The American multinational company Merck & Co was founded in 1891 by Friedrich, Heinrich, and George Merck and headquartered in Kenilworth, New Jersey. 

This world’s biggest and one of the list of pharma companies in the US is known for its autoimmune disorder, type-2 diabetes, cancer disease, and other medical conditions as well as other medical health products.

The total revenue generated in the year 2021 was $48.77 billion which is an increase of 17% compared to 2020.

In this revenue, keytruda, one of the best-selling drugs worldwide made sales of $17.2 billion, and another cancer drug with the generic name pembrolizumab increased its sales by $2.8illion.

5) Bristol Myers Squibb

Revenue 2021: $46.385 billion

Headquarters: New York.

Founded in the year 1887 by two friends William McLaren Bristol and John Ripley Myers, Bristol Myers Squibb is headquartered in New York.

It is a global pharmaceutical company committed to improving patient life by delivering truly innovative medicines that help patients prevail over serious diseases.

This company provides medicines for cancer, HIV/AIDS, cardiovascular disease, diabetes, hepatitis, and psychiatric disorders.

In the year 2021, it generated total revenue of $46.385 billion with an increase of 9.09%.

Top-selling products in 2021 were Revlimid and Opdivo, drugs used in the treatment of certain cancers, and Eliquis, an anticoagulant.

6) Abbott laboratory

Revenue 2021: $43.075 billion

Headquarters: Lake Bluff.

Founded in the year 1888 by Dr. Wallace C. Abbott, Abbot Laboratory was Headquartered in the Abbott Park Business Center in Lake Bluff.

It is actively engaged in medical devices, diagnostics, generic medicines, and nutritional products.

The company generated total revenue of $43.075 billion in the year 2021 with an increase of 24.47%.

Diagnostics and medical devices were top-selling segments in 2021 and generated 14.3 and 15.6 US dollars.

7) Eli Lilly and Company

Revenue 2021: $28.32 billion

Headquarters: Indianapolis

Eli Lilly and Company was founded by Colonel Eli Lilly in the year 1876 and has its headquarters in Indianapolis with offices in 18 other countries and reputed US based pharma companies.

This was the first company for the mass production of Penicillin, insulin, and the Salk Polio vaccine.

They are currently involved in the manufacturing of physiatrists’ medications and produce Prozac, Dolophine, Cymbalta, and Zyprexa, and their products are sold in almost 125 countries.

In the year 2021, the company generated total annual revenue of $28.32 billion with a 15% rise compared to 2020.

8) Gilead sciences

Revenue 2021: $27.350 billion

Headquarters: Foster City, California

In the year 1987, Michael L. Riordan founded the company which is located in Foster City, California.

Along with the United States, Gilead Science operates in North America, Europe, and Australia. 

This pharma manufacturing company in the US is actively involved in the manufacturing of antiviral drugs used in the treatment of HIV, Hepatitis B, Hepatitis C, and influenza.

In 2021, the company made a total annual revenue of $27.350 billion with an increase of 10.6% compared to 2020.

9) Amgen

Revenue 2021: $25.979 billion 

Headquarters: Thousand Oak, California.z

Founded by George Rathmann in the year 1980, Amgen is headquartered in Thousand Oak, California.

This American pharmaceutical multinational company is one of the largest independent companies in the world.

The company generated total revenue of $25.979 billion with an increase of 2.18%. compared to 2020.

10) Biogen

Revenue 2021: $10.98 billion 

Headquarters: Cambridge, MA

It was founded in 1978 by Charles Weissman, Heinz Schaller, Kenneth Murray, and Nobel Prize winners Walter Gilbert and Phillip Sharpiogen. 

The company’s main focus is to discover, develop, manufacture, and market innovative therapies for the global patient population with neurological and neurodegenerative diseases.

Biogen is one of the oldest independent biotechnology companies in the world.

In 2021 Biogen generated total annual revenue of $10.98 billion With an 18.32% decline from 2020.

In 2021, Spinraza was top selling healthcare product and generated revenues of around $1.9 billion.

The effect of Covid-19 on R&D

The various variants of covid-19 and their dreadful effects on humans have pushed pharmacists to invest great time, energy, and money in R&D of medicines that save people from this dreadful virus.

According to Statista, in 2021, the R&D expenditure of US pharma companies totaled some $102 billion, and this is going to increase due to the cost associated with developing safe and effective Covid-19 vaccines and treatments.

The high cost of prescription drugs

In recent years, the US has made great profits due to the high cost of prescription drugs.

The blockbuster medicine Humira produced by AbbVie made sales of $17 billion in the year 2021. 

Even after factoring in discounts and rebates total spending on medicine in the US exceeds half a trillion billion US dollars. 


Thus, the top pharma companies in the USA are continuously working towards developing and manufacturing innovative drugs that help patients to prevail and fight against dreadful diseases, and improve their lifespan. 

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Ampliz is the answer.

Ampliz holds extensive contact lists of top pharma companies in the USA. Ampliz provides you with the most authentic, updated, and customized top pharmaceutical contact lists of the USA and helps your business to achieve predetermined business goals.

FAQs On US pharmaceutical companies

How many US pharmaceutical companies are there?

According to IBISWorld, There are 2,655 brand name Pharmaceutical Manufacturing companies in the US as of 2023.

At Ampliz, we have high-end datasets of US pharmaceutical companies.

Who is the No 1 pharma company in USA?

Johnson and Johnson is the no. 1 pharma company in USA.

What are the big 4 pharmaceutical companies?

1) Jhonson and Johnson
2) Pfizer
3) AbbVie.Inc
4) Merck & Co

Who are the largest drug distributors USA?

Cardinal Health, AmerisourceBergen, and McKesson Corporation are the largest drug distributors in USA.

Almost 90% drugs in the United States are distributed through these wholesalers.