Nonprofit health systems anchor the U.S. hospital market. They run many of the country’s most renowned academic medical centers, regional referral hubs, and community hospitals and they’re the buyers behind billions of dollars in clinical supplies, devices, software, and services each year. For vendors, understanding who the largest nonprofit systems are, how big they are, and how they buy is the difference between opportunistic outreach and a repeatable enterprise pipeline.
This guide gives you an updated, vendor focused view of the biggest nonprofit health systems in 2025. We’ll:
- Explain why “largest” can mean different things (total revenue vs. net patient revenue vs. beds/hospitals).
- Share a ranked table of the top nonprofit systems by latest reported revenue (FY2024 / most recent 12-month periods).
- Answer: How many largest nonprofit systems are there?
- Break down buying centers, decision dynamics, and what resonates in enterprise outreach.
- Show you how to reach these systems faster with Ampliz healthcare data intelligence.
Why “largest” differs by metric?
Before the table, a quick calibration:
- Total operating revenue: Captures the full enterprise (e.g., hospitals, physician groups, health plans). Integrated systems like Kaiser Permanente look especially large because they include insurance revenue. Industry lists using this lens are best for estimating overall purchasing power.
- Net patient revenue (NPR): Hospital/IDN revenue tied to care delivery; excludes some plan income. Useful for pure provider comparisons. CommonSpirit and Kaiser rank near the top here as well.
- Beds / hospital count: A scale proxy. For example, CommonSpirit and Ascension operate extensive multi-state footprints; VA is the largest by beds but is a federal system rather than a traditional private nonprofit.
For vendors, revenue-based rankings are the most practical when prioritizing accounts for enterprise sales.
The 25 Largest US Nonprofit Health Systems
| # | Health system (nonprofit) | HQ | Revenue (USD, latest) | Notes |
|---|---|---|---|---|
| 1 | Kaiser Permanente | Oakland, CA | ~$115.8B (total revenue) | Integrated plan + provider drives the nation’s largest nonprofit health enterprise. |
| 2 | CommonSpirit Health | Chicago, IL | ~$37.0B (total revenue) | One of the largest multi-state Catholic systems; extensive acute footprint. |
| 3 | Advocate Health | Charlotte, NC | ~$31.7B (total revenue, latest available) | Formed from Advocate Aurora + Atrium; strong Southeast/Midwest presence. |
| 4 | Providence | Renton, WA | ~$30.7B (total revenue) | Large West Coast and Mountain footprint; Catholic heritage. |
| 5 | UPMC | Pittsburgh, PA | ~$29.9B (total revenue) | Major insurer-provider (UPMC Health Plan) + academic/tertiary centers. |
| 6 | Ascension | St. Louis, MO | ~$28.6B (total revenue) | Catholic, multi-regional; major purchaser across service lines. |
| 7 | Trinity Health | Livonia, MI | ~$23.9B (total revenue) | Catholic system; FY2024 returned to positive operations. |
| 8 | Mass General Brigham | Somerville, MA | ~$20.6B (total revenue) | Academic powerhouse (Mass General, Brigham and Women’s). |
| 9 | Mayo Clinic | Rochester, MN | ~$19.8B (total revenue) | Integrated care + research + education; global referral leader. |
| 10 | Intermountain Health | Salt Lake City, UT | ~$17.1B (total revenue) | Vertical integration with SelectHealth plan; strong Mountain West scale. |
| 11 | Northwell Health | New Hyde Park, NY | ~$16.9B (total revenue, latest available) | New York’s largest private employer; multi-borough reach. |
| 12 | Corewell Health | Southfield, MI | ~$16.4B (total revenue) | Former BHSH (Beaumont + Spectrum); statewide scale across MI. |
| 13 | Sutter Health | Sacramento, CA | ~$16.1B (total revenue) | Northern California integrated network of hospitals/clinics. |
| 14 | Cleveland Clinic | Cleveland, OH | ~$15.9B (total revenue) | Quaternary/complex care leader with national & international sites. |
| 15 | Banner Health | Phoenix, AZ | ~$15.6B (total revenue) | Sun Belt scale; payer-provider experiments and ambulatory expansion. |
| 16 | Baylor Scott & White Health | Dallas, TX | ~$15.5B (total revenue) | Largest nonprofit system in Texas by revenue; robust ambulatory network. |
| 17 | Jefferson Health | Philadelphia, PA | ~$15.0B (total revenue) | Academic + community mix; strong mid-Atlantic presence. |
| 18 | NYU Langone Health | New York, NY | ~$14.2B (total revenue) | Rapid growth in NYC metro; strong specialty lines. |
| 19 | Bon Secours Mercy Health | Cincinnati, OH | ~$13.3B (total revenue) | Large Catholic system spanning U.S. and international sites. |
| 20 | SSM Health | St. Louis, MO | ~$11.4B (total revenue) | Catholic, multi-state; payer partnerships and virtual care growth. |
| 21 | BJC HealthCare | St. Louis, MO | ~$10.7B (total revenue) | Academic/community system in the Midwest (Washington University ties). |
| 22 | Novant Health | Winston-Salem, NC | ~$10.2B (total revenue) | Southeast regional system with strong physician enterprise. |
| 23 | Northwestern Medicine | Chicago, IL | ~$9.6B (total revenue) | Academic hub (Northwestern Memorial) + regional network. |
| 24 | Mercy (MO) | Chesterfield, MO | ~$9.3B (total revenue) | Multi-state Catholic system with strong telehealth adoption. |
| 25 | Indiana University Health | Indianapolis, IN | ~$9.2B (total revenue) | Statewide academic system anchored by IU School of Medicine. |
how many largest nonprofit systems are there?
There are hundreds of nonprofit health systems in the US if you include every regional and community IDN. However, when vendors say “the largest,” they generally mean the top 20–30 national-scale nonprofits that dominate spend across categories. In procurement terms, the 25 listed above are a practical definition of the largest cohort for enterprise selling in 2025.
What makes these systems different as buyers?
1) Centralized contracting + local value analysis
Most large nonprofits source through a GPO (e.g., Vizient, Premier, HealthTrust) with local value-analysis committees (VACs) and service-line councils. Expect RFPs, evidence requirements (clinical + financial), and standardization pressures.
2) Payer-provider dynamics influence ROI
Systems with integrated health plans (Kaiser, UPMC, Intermountain) scrutinize solutions for total cost of care impact (utilization reduction, site-of-care shifts, readmits). Be ready with claims-adjacent outcomes and actuarial logic.
3) System-wide digital front doors
At-scale nonprofits prioritize access, throughput, workforce productivity, and revenue integrity. Solutions that unlock OR time, reduce LOS/boarding, or automate no-show management and prior auth get executive attention.
4) ESG and community benefit narratives
Nonprofits face growing scrutiny on charity care vs. tax exemptions. Framing your value in terms of health equity, access, and measurable community impact is increasingly table stakes.
Outreach playbook: who decides and what to bring
Buying centers you must map
- System supply chain / strategic sourcing (RFPs, terms, standardization)
- Service-line leadership (e.g., cardiovascular, ortho, oncology)
- Clinical quality & VACs (clinical evidence, change management)
- IT / digital / data science (security, integration, analytics)
- Revenue cycle & finance (margin guardrails, cash acceleration)
- Population health / health plan (if applicable) (TCOC outcomes)
Evidence toolkit that wins cycles
- Comparative clinical outcomes (risk-adjusted), time-motion and workflow improvements
- Clear ROI models tied to DRGs, CPT/HCPCS, supply utilization, staffing ratios, denials
- Implementation pathway with 90-day milestones, training and adoption metrics
- Security & compliance package (HIPAA, SOC 2, HITRUST where relevant)
- References from peer systems of similar scale/setting
How to reach these Healthcare systems using Ampliz?
Breaking into the largest nonprofits requires precision targeting and multi-threaded outreach across corporate, regional, and facility levels. Ampliz shortens this path by giving you clean, verified, and role-mapped decision-maker data plus the firmographics and technographics to tailor your pitch.
With Ampliz, you can:
- Build named-account lists for the exact systems above, filtered by bed size, NPR, service lines, teaching status, GPO, and geographic clusters.
- Pull decision-maker org charts—from system C-suite (CFO, CIO, CMO, CNO) down to service-line admins and supply chain directors—with validated emails and direct dials.
- Segment by technology stack (EHR, ERP, rev-cycle, scheduling, telehealth), so you tailor your ROI to their environment (e.g., Epic-first workflows vs. Cerner/Oracle).
- Trigger outreach on buying signals: expansions, bond issuances, leadership moves, service-line volumes, and financial performance swings.
- Enrich your CRM to de-duplicate, standardize facility names (campus vs. system), and auto-roll up contacts under the correct IDN parent—critical for accurate forecasting.
Messaging Angles that resonate with large nonprofits
- Throughput & access: “We helped a 1,000-bed nonprofit cut ED-to-admit boarding by 22% and add 3 OR blocks/day without additional staff.”
- Labor productivity: “Automated clinical documentation reduced RN after-shift charting by 35 minutes per nurse per shift.”
- Revenue integrity: “Denials prevention improved first-pass yield by 2.8 pts within 120 days.”
- Equity & community benefit: “Closed-loop referrals hit 77% in target ZIPs; charity-eligible patients identified upfront rose 18%.”
Ampliz lets you target the right buyers with the right proof and scale the approach across the top 25 accounts fast.
Conclusion: The bottom line for vendors
The U.S. market features hundreds of nonprofit systems, but 25 national-scale nonprofits control a disproportionate share of spend and standard-setting. Start there.
Use revenue-based rankings for account prioritization, and validate tactical nuances (beds, hospitals, NPR) when sizing service lines.
Enterprise deals move through supply chain + clinical + IT + finance. Your pitch needs clinical proof, operational impact, and P&L clarity—all mapped to their EHR/ERP stack.
Ampliz gives you the decision-maker map, data hygiene, and buying-signal enrichment to open doors and prove value faster.
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