Prolynx LLC

Biotechnology

Headquarters: 455 Mission Bay Blvd South, Suite 145, San Francisco, CA, United States, 94158

Phone: (415) 552-5306

Website: www.prolynxllc.com

Founded: 2009

Employees: 11-50

Stock Exchange: NA

About Prolynx LLC

ProLynx LLC (San Francisco, CA), founded in 2009 by Daniel V. Santi, M.D., Ph.D., and Gary W. Ashley, Ph.D., has developed advan ... ced linker technologies and a facile, transformative platform for controlled release of therapeutics from circulating and fixed macromolecular conjugates. ProLynx’s technology platform is dedicated to the development of linker systems to enable predictable and controllable half-extension of drugs – including peptides, proteins and small molecules -- using macromolecular and fixed supports (s.c. & i.v. injectables, implants, others). Unlike competing technologies – which depend on ester-cleaving linkers with half-lives of 12 to 24 hrs – we have “self-cleaving” chemical linkers that release the native drug with half-lives ranging from hours to months. We have applied this technology to three programs. A small molecule, SN38, which is a topoisomerase inhibitor, is linked to the inert matrix PEG through our programmable linkers. This PEG~SN38 (PLX038) is currently in Phase I clinical trials for solid tumors at the MD Anderson. We expect to complete this trial by the end of 2017. PLX039, is a subcutaneous, once monthly GLP1 receptor agonist. Here, the peptide is linked to the hydrogel matrix. The peptide is released from this depot with a half-life of a month. We are initiating GLP toxicity studies and expect to initiate Phase I clinical trials by the end of 2018. PLX040 is a subcutaneous, long-acting octreotide. Unlike sandostatin LAR, which is a deep intramuscular injection through an 18 gauge needle, PLX040 can be self-administered through a small-bore 27 - 29 gauge needle. Show more

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Frequently Asked Questions Regarding Prolynx LLC

Where are Prolynx LLC’s headquarters?

Prolynx LLC’s headquarters are in 455 Mission Bay Blvd South, Suite 145, San Francisco, CA, United States, 94158

What is Prolynx LLC’s industry?

Prolynx LLC is in the industry of: Biotechnology

What is Prolynx LLC’s phone number?

Prolynx LLC’s phone number is (415) 552-5306

What is Prolynx LLC’s official website?

Prolynx LLC’s official website is www.prolynxllc.com

How many employees are working in Prolynx LLC?

Prolynx LLC has 11-50 employees

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